Computational science which includes computational intelligence ci has recently become the third method of scientific enquiry besides theory and experimentation there have been fast growing interests in developing and applying ci in disease mapping using snp and haplotype data some of the recent studies have demonstrated the promise and importance of ci for common complex diseases in . Computational intelligence ci is a well established paradigm with current systems having many of the characteristics of biological computers and capable of performing a variety of tasks that are difficult to do using conventional techniques. Computational intelligence ci is a well established paradigm with current systems having many of the characteristics of biological computers and capable of performing a variety of tasks that are difficult to do using conventional techniques. Computational intelligence poses several possibilities in bioinformatics particularly by generating low cost low precision good solutions rough sets promise to open up an important dimension in this direction the present article surveys the role of artificial neural networks fuzzy sets and genetic algorithms with particular emphasis on rough sets in bioinformatics since the work . Computational intelligence in bioinformatics studies in computational intelligence computational intelligence wikipedia the expression computational intelligence ci usually refers to the ability of a computer to learn a specific task from data or experimental observation even though it is commonly considered a synonym of soft computing there is still no commonly accepted definition of